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KMID : 1145520150010010046
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Journal of Radiopharmaceuticals and Molecular Probes
2015 Volume.1 No. 1 p.46 ~ p.52
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Synthesis of 68Ga-labeled gold nanoparticles for tumor targeted positron emission tomography imaging
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Jeon Jong-Ho
Choi Mi-Hee
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Abstract
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Herein we present the synthesis of 68Ga-labeled gold nanoparticles for in vivo PET imaging. A novel chelator DTPA-Cys was easily prepared from diethylenetriaminepentaacetic dianhydride in high yield. The ?vβ3 integrin receptor targeted gold nanoparticle probe was synthesized by using DTPA-Cys, polyethylene glycol and cRGD peptide. 68Ga labeling of cRGD conjugated gold nanoparticle was carried out at 40o C for 30 min. Observed radiochemical yield was more than 75% as determined by radio-TLC and the probe was purified by centrifugation. In vitro stability test showed that 90% of 68Ga-labeled gold nanoparticle probe was stable in FBS for 1 h. Those results demonstrated that 68Ga-labeled gold nanoparticle could be used as a potentially useful probe for specific tumor imaging.
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KEYWORD
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Gold nanoparticle, 68Ga, Radiolabeling, Molecular imaging, Positron emission tomography
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